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Image Search Results
Journal: The Journal of physiology
Article Title: Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice
doi: 10.1113/JP282112
Figure Lengend Snippet: Representative whole-mount images of olfactory bulbs following beta-galactosidase histological staining of Olfr160-expressing olfactory sensory neurons (OSNs) from A, male and B, female M72tauLacZ mice following dietary treatments; images from left to right: control diet ad libitum (brown food symbol), control diet isocaloric pair-fed (brown food and scale symbol), moderately high-fat diet ad libitum (pink food symbol), moderately high-fat diet isocaloric pair-fed (pink food and scale symbol). Corresponding gray scale images were used for pixel determination in (C). o = olfactory bulb, g = glomerulus, and a = Olfr160 axonal projections. C, Bar graph of total Olfr160 axon projections vs diet treatment in male (left) and female (right) mice. Symbols represent individual mice sampled from left to right: CF adlib = control diet ad libitum (⬛), CF pair = control diet isocaloric pair fed (⬜), MHF adlib = moderately high-fat diet ad libitum (●), MHF pair = moderately high-fat diet isocaloric pair-fed (○). Data are reported as mean ± standard deviation in this and all subsequent figures. Sample size of number of mice from left to right, Male = 8, 8, 9, 9 | Female = 9, 9, 9, 9. One-way analysis of variance (1-way ANOVA) across treatment groups within each sex. Degrees of freedom, F test, and p value of the ANOVA are reported in each figure panel, here and in subsequent figures. Letters indicate significantly different Tukey’s post-hoc test corrected for multiple comparisons, p < 0.05.
Article Snippet: Mice were maintained on either a control diet (CF) of Purina 5001 Rodent Chow (28.05% kCal protein, 59.81% kCal carbohydrate, and 13.5% kCal fat; https://www.labdiet.com/Products/StandardDiets/Rodents/index.html ) or a Moderately
Techniques: Staining, Expressing, Control, Standard Deviation
Journal: The Journal of physiology
Article Title: Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice
doi: 10.1113/JP282112
Figure Lengend Snippet: A, Representative whole-mount images of olfactory bulbs following beta-galactosidase histological staining of Olfr160-expressing olfactory sensory neurons (OSNs) from male M72tauLacZ mice following diet/exercise treatments; images from left to right: control diet ad libitum (brown food symbol), control diet plus running wheel (brown food and wheel symbol), moderately high-fat diet ad libitum (pink food symbol), moderately high-fat diet plus running wheel (pink food and wheel symbol). Projections were converted to pixel density and OSNs manually counted as in Figs. 2//3.3. o = olfactory bulb, g = glomerulus, and a = Olfr160 axonal projections. Bar graph of B, pixel density of axonal projections and C, number of Olfr160-expressing OSNs vs. diet/exercise treatment; CF Sed = control diet sedentary, CF VEx = control diet voluntary exercise, MHF = moderately high-fat diet sedentary, MHF Vex = moderately high-fat diet voluntary exercise. D, Line graph of body weight vs. age; 2-way RM ANOVA; symbols indicate significantly different for treatment factor as determined by Tukey’s post-hoc (p < 0.05) as follows: # = MHF Sed > both CF groups; ♦ = MHF VEx > both CF groups; * = MHF Sed > MHF VEx. E, Bar graph of body weight vs. diet/exercise treatment at 25 weeks of age. F, Line graph of the plasma glucose concentration and G, bar graph of the iAUC during the IPGTT. H, Bar graph of the total excised adipose tissue vs. diet/exercise treatment. Notations as in Fig. 2. (B, C, E, G, H) 1-way ANOVA, Tukey’s post-hoc, p < 0.05. Sample sizes in number of mice from left to right for whole mount: 14, 9, 12, 9 | for neuronal counts: 11, 8, 10, 8 | for body weight and IPGTT: 14, 9, 12, 9 | and for adipose tissue = 11, 9, 12, 9.
Article Snippet: Mice were maintained on either a control diet (CF) of Purina 5001 Rodent Chow (28.05% kCal protein, 59.81% kCal carbohydrate, and 13.5% kCal fat; https://www.labdiet.com/Products/StandardDiets/Rodents/index.html ) or a Moderately
Techniques: Staining, Expressing, Control, Clinical Proteomics, Concentration Assay